Thank you Andrew, Rick and Roger for your insight on this. Roger, when you say 'ISO coated may be a better choice', what does that mean? Is 'ISO coated' any profile that meets 12647 standards like GRACoL 2006 or SWOP 2006 ? Also, what did you think about my question below about converting to GRACoL 2006 before sending to the Epson? Thanks again. "Along the same lines, I'm helping a friend setup an Epson 7900 proofing edition with EFI XF 4.1. They send untagged PDF/X-1a documents to the RIP from indesign CS3. We plan to set up the Epson with GRACoL certification and the training videos suggest setting the "CMYK source" in EFI to CoatedGRACol2006.icc Does that mean the PDF/X-1a from indesign (and the included images) should also be in the CoatedGRACol2006 space before it is sent to the RIP untagged?"
So, to conclude, I would personally tend not to use SWOPv2 as the default because SWOPv2 represents an inherently yellow substrate and will render all colors with that tint of yellow that they don't originally have, most likely. I would tend to think that ISO Coated might be a better choice, but again so is SWOP2006_C3.
Best / Roger